Methylsulfonylmethane
MSM
Supports structural integrity and normal cellular maintenance

MSM is included as part of Essential's daily maintenance active ingredients and Move's hip & Joint support active ingredients.
In Essential, mSM (Methylsulfonylmethane) is a bioavailable source of sulfur, an essential element for the structure of proteins, enzymes, and connective tissues. It contributes to the synthesis and maintenance of key structural components in the body and supports cellular integrity and metabolic processes. Its role within the formula is to help maintain the body’s structural and biochemical balance.
In Move, mSM is an organic sulfur compound that contributes sulfur to biological systems involved in structural proteins, connective tissue, and cellular maintenance. In mobility formulas, MSM supports the broader maintenance of tissues that help the body move well, including muscles, connective tissues, and antioxidant systems. Its role in Move is to support whole-body maintenance around active movement, rather than being positioned narrowly as a joint-only ingredient.
Research notes
References for further reading
- Moreau, M., Troncy, E., del Castillo, J.R.E., Bedard, C., Gauvin, D., Lussier, B. and Moreau, M. (2022) ‘Nutraceuticals in the clinical management of osteoarthritis in dogs and cats: a systematic review’, BMC Veterinary Research, 18, 68
- Butawan, M., Benjamin, R.L. and Bloomer, R.J. (2017) ‘Methylsulfonylmethane: applications and safety of a novel dietary supplement’, Nutrients, 9(3), 290
- Withee, E.D., Tippens, K.M., Dehen, R., Tibbitts, D., Hanes, D. and Zwickey, H. (2017) ‘Effects of methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial’, Journal of the International Society of Sports Nutrition, 14, 24










